Sponsored Satellite Program: Exploring the Role of Selected Vitamins and Essential Nutrients in Cognition: Impact of Supplementation on Neurodegeneration
Sponsored By: ChromaDex and Balchem
This Sponsored Satellite Program was originally presented at NUTRITION 2022 LIVE ONLINE.
Age-related cognitive decline and neurodegenerative diseases can be exacerbated by exposure to various metabolic stresses over time, such as oxidative stress and inflammation. Nutritional interventions may be able to counter these effects and slow or delay functional decline. Preclinical models exist to assess the effect of various bioactive dietary components on cognitive decline. These models have been utilized to demonstrate the critical role of nutritional components such as the coenzyme nicotinamide adenine dinucleotide (NAD) and the essential nutrient choline in the normal function of neural tissue. Studies in preclinical models have demonstrated that interventions with nutrients such as nicotinamide riboside (NR) and choline can lead to beneficial changes in the brain and nervous system, including increasing NAD concentrations and altering epigenetic modifications in the brain. This research has in turn informed the design and execution of pilot human clinical trials aimed at investigating the effect of these nutrients on neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, with several additional trials underway. These studies suggest that supplementation with nutrients such as NR or Choline may be effective interventions to slow or delay functional declines that are characteristic of neurodegenerative disease.
- Describe the basic role NAD and Choline play in neuronal function
- Explain the mechanism of action for how NR and Choline supplementation impact neurodegenerative disease progression
- Describe the latest results from the most recent clinical trials on NR and Choline supplementation for neurogenerative disease
This Sponsored Satellite Program includes the following presentations:
- Restoring Lipid Balance in Carriers of the Alzheimer’s Disease Risk Factor APOE4 by Dietary Choline Supplementation
- Impact of Nicotinamide Riboside (NR) on Models of Alzheimer’s Disease
- The NADPARK Study: A Randomized Phase I Trial of NR Supplementation in Parkinson’s Disease
- Panel Discussion
Chair: Joshua W. Miller, PhD – Professor & Chair of Nutritional Sciences, Department of Nutritional Sciences, Rutgers University
Speaker: Jim Ray, PhD – Executive Director, Neuroscience, The Neurodegeneration Consortium MD Anderson Cancer Center
Speaker: Vilhelm Bohr, MD, PhD – Laboratory Chief, Laboratory of Molecular Gerontology, National Institutes on Aging, National Institutes of Health
Speaker: Charalampos Tzoulis, MD, PhD – Haukeland University Hospital, University of Bergen, Norway
- 1.50 Attendance
Learners are eligible to download a Certificate of Attendance upon activity completion. A Certificate of Attendance confirms the learner has completed the activity and does not confer any continuing education credit to the learner from ASN.