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Studying development, diseases and gut microbiome is extremely challenging in animal models, and many factors need to be considered during the design phase. In particular, the diets chosen will have a strong impact on data outcomes and interpretation, and directly affects inflammation, metabolism and microbiome results, ultimately affecting the disease development in the animals, including metabolic and inflammatory-associated diseases. The first portion of the webinar will provide an overview of what diets are used in lab animal research, factors that can have a direct impact on your research, and what needs to be considered when planning diet-driven disease studies. The second portion of the webinar will include a pilot study using the neonatal piglet model that ensured nutritional recommendations are met for the growing piglet. This study design then allowed the space to examine the main differences between the study diets in relation to developmental outcomes.

Organized by ASN's Experimental Animal Nutrition RIS and Nutritional Immunology and Inflammation RIS

Speakers

Yimin Chen, PhD, RDN
University of Idaho

Michael Pellizzon, PhD, FASN    
Research Diets, Inc.

Learning Objectives

1. Describe an overview of commonly used diets in lab animal research
2. Provide useful tips for what needs to be considered when planning diet-driven studies in rodent models
3. Describe the differences in the microbiome, gut inflammation, and metabolome between human milk vs. infant formula-fed piglets
4. Compare markers of neurodevelopment and neuroinflammation between human milk vs. infant formula-fed piglets